The functional requirements for high-speed Mixing Granulator are as follows:
1. The mixing paddle is dry mixed with the material, and the mixture is wet mixed after adding the binder. According to the characteristics of the material and the adhesive, the rotation speed of the stirring paddle ensures that the motion generates eddy current and the material is thoroughly mixed. At the same time, the material of the tumbling at the intersection of the knives is fully broken into granules.
2. The rotation speed of the stirring paddle and the granulating knife can make the material produce three-dimensional motion, the particles collide, rub and shear, make the friction uniform and detailed, and finally shape the stable spherical particles. The mixing time, the speed of the stirring paddle and the granulating knife, the granulation quality after drying and the uniformity satisfy the requirements of the solid preparation production process.
3. The mixing granulation process should be in the closed state, the whole process of mixing granulation (including feeding, mixing, cutting granulation and unloading, etc.) should work under the cleanliness of 100,000 or 300,000 class, and ensure no foreign matter. fall.
4. The machine can be connected with the boiling drying or lifting feeding or vacuum feeding machine equipment.
As a Mixing Granulator Manufacturer, we know that the particles prepared by wet mixing granulation are irregular in shape, uniform in particle size distribution, and the structure is better than other conventional granulation processes, but the granulated finished product involves many factors, and its influence is now Brief description.
1. The influence of stirring paddle and cutter speed
It can be said that the size and distribution of the particle size are directly related to the rotation speed of the stirring paddle and the cutting blade. When the cutting speed is slow, the particle size becomes larger, while the rotating speed is faster, the particle size becomes smaller; when the stirring paddle rotates slowly, the particles The particle size is small, and the particle size is large when the rotation speed is fast, and the two functions are opposite.
2. Mixing, granulation procedures and time effects
Because in the operation of the high-speed mixing granulator, the rotation of the stirring paddle causes the material in the pot to roll into the space, so that the material of the bottom of the pot is thrown up along the wall of the pot. This action pushes the soft material to the quick cutting knife one by one, and is The particles are cut into different sizes, and are gradually rounded as the particles roll over each other for a while. It can be seen that the speed and time of the stirring paddle and the cutting blade have an effect on the particle size of the granulation.
3. Influence of materials and concentration
In wet mixed granulation production, alcohol granulation or dextrin binder is commonly used for granulation, and the adhesion of the two is determined to be different. It is common to use alcohol to make granules. The granules are small and fine, and easy to dry. This is because alcohol does not have viscosity, and it has a loose effect. This method is ideal for granulation of high-viscosity Chinese medicine. When the paste is used to refine the granules, the granules produced are large and coarse, and the drying is slow. This is because the dextrin is sticky and has a polymerization effect, and the medicinal preparation having no viscosity is preferable.
In addition, whether it is diluted with concentrated extract as a material or a material using dextrin or other binder, when producing smaller particles, the slurry concentration of the material can be thinner. When larger particles are required, the material is The slurry concentration can be slightly stronger.
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